Is factory farming to blame for coronavirus?

22/04/20
Author: 
Laura Spinney
 A Chinese poultry farm. China stepped up surveillance after bird flu outbreaks. Photograph: China Photos/Getty Images
28 March 2020 
 
Scientists are tracing the path of Sars-CoV-2 from a wild animal host – but we need to look at the part played in the outbreak by industrial food production

Where did the virus causing the current pandemic come from? How did it get to a food market in Wuhan, China, from where it is thought to have spilled over into humans? The answers to these questions are gradually being pieced together, and the story they tell makes for uncomfortable reading.

Let’s start at the beginning. As of 17 March, we know that the Sars-CoV-2 virus (a member of the coronavirus family that causes the respiratory illness Covid-19) is the product of natural evolution. A study of its genetic sequence, conducted by infectious disease expert Kristian G Andersen of the Scripps Research Institute in La Jolla, California, and colleagues, rules out the possibility that it could have been manufactured in a lab or otherwise engineered. Puff go the conspiracy theories.

The next step is a little less certain, but it seems likely that the original animal reservoir for the virus was bats. Andersen’s team showed – like the Chinese before them – that the sequence of Sars-CoV-2 is similar to other coronaviruses that infect bats.

Since other bat coronaviruses have transited to humans via an intermediate animal host, it seems likely that this one did too. That animal was probably one that some Chinese people like to eat, and that is therefore sold in “wet” markets (those that sell fresh meat, fish, seafood and other produce). This animal may have been the scaly mammal called a pangolin. That can’t be conclusively proved, but several groups have found sequence similarities between Sars-CoV-2 and other coronaviruses that infect pangolins.

If this is indeed the route the virus took to humans, it has two critical interfaces: one between us and the intermediate host, possibly a pangolin, and one between that host and bats. Most of the attention so far has been focused on the interface between humans and the intermediate host, with fingers of blame being pointed at Chinese wet markets and eating habits, but both interfaces were required for the pandemic to ignite. So where and how did the spillover from the bat to the pangolin – or other wild or semi-wild intermediate host – occur?

“Our study does not directly shed light on the geographical origin of the virus,” says Andersen. “However, all the available evidence shows that it was inside China.”

Case closed then, and President Trump is right to call Sars-CoV-2 the “Chinese virus”. Well, no, because if you want to understand why this pandemic happened now and not, say, 20 years ago – since Chinese people’s taste for what we in the west consider exotic fare is not new – you have to include a number of other factors. “We can blame the object – the virus, the cultural practice – but causality extends out into the relationships between people and ecology,” says evolutionary biologist Rob Wallace of the Agroecology and Rural Economics Research Corps in St Paul, Minnesota.

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The closed Huanan Seafood Wholesale Market in Wuhan, in China’s Hubei Province, in January. Photograph: Noel Celis/AFP via Getty Images

Starting in the 1990s, as part of its economic transformation, China ramped up its food production systems to industrial scale. One side effect of this, as anthropologists Lyle Fearnley and Christos Lynteris have documented, was that smallholding farmers were undercut and pushed out of the livestock industry. Searching for a new way to earn a living, some of them turned to farming “wild” species that had previously been eaten for subsistence only. Wild food was formalised as a sector, and was increasingly branded as a luxury product. But the smallholders weren’t only pushed out economically. As industrial farming concerns took up more and more land, these small-scale farmers were pushed out geographically too – closer to uncultivable zones. Closer to the edge of the forest, that is, where bats and the viruses that infect them lurk. The density and frequency of contacts at that first interface increased, and hence, so did the risk of a spillover.

It’s true, in other words, that an expanding human population pushing into previously undisturbed ecosystems has contributed to the increasing number of zoonoses – human infections of animal origin – in recent decades. That has been documented for Ebola and HIV, for example. But behind that shift has been another, in the way food is produced. Modern models of agribusiness are contributing to the emergence of zoonoses.

Take flu, a disease that is considered to have high pandemic potential, having caused an estimated 15 pandemics in the past 500 years. “There is clearly a link between the emergence of highly pathogenic avian influenza viruses and intensified poultry production systems,” says spatial epidemiologist Marius Gilbert of the Université Libre de Bruxelles in Belgium.

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A pangolin, the scaly mammal thought to be a possible intermediate host for the coronavirus.
 

The reasons, many of which were documented in Wallace’s 2016 book Big Farms Make Big Flu, include the density with which chickens, turkeys or other poultry are packed into factory farms, and the fact that the birds in a given farm tend to be near genetic clones of one another – having been selected over decades for desirable traits such as lean meat. If a virus gets introduced into such a flock, it can race through it without meeting any resistance in the form of genetic variants that prevent its spread. Both experimental manipulations and observations in the real world have demonstrated that this process can result in a ratcheting up of the virus’s virulence. If it then spills over into humans, we are potentially in trouble.

In a paper published in 2018, Gilbert’s group reviewed historical “conversion events”, as they call them – when a not-very-pathogenic avian flu strain became much more dangerous, and found that most of them had occurred in commercial poultry systems, and more frequently in wealthy countries. Europe, Australia and the US had generated more of them than China.

That doesn’t let China off the hook. Two highly pathogenic forms of avian flu – H5N1 and H7N9 – have emerged in that country in recent decades. Both infect humans, though not easily (yet). The first human cases of H7N9 were reported in 2013, and there were small annual outbreaks thereafter. But, says Gilbert, “nothing was done until the virus turned out to be pathogenic for chickens as well. Then it became an important economic issue and China started to mass-vaccinate its poultry against H7N9, and that ended the transmission to humans.”