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YENAGOA, Nigeria, Dec 2 (Reuters) - A large oil spill near Nigeria's Brass facility, run by ENI, has spread through the sea and swamps of the oil producing Niger Delta region, local residents and the company said on Monday. ENI said it was not yet possible to determine the cause of the spill. There are hundreds of leaks every year from pipelines that pass through the delta's creeks, damaging the environment and the profits of oil companies including ENI and Royal Dutch Shell , especially when production has to be deferred.